21 The month of january: “–pull variety” and “–prohibit range” not mistake away when its enter in files consist of good chromosome password absent on most recent dataset.
: Repaired –meta-analysis-se-profession insect. –meta-analysis-chr-profession and you can –meta-analysis-bp-occupation flags added. In the development generate, –dfam constantly errors away which have the ideal content, in the place of perhaps segfaulting, when zero legitimate cases exist.
twenty-eight Oct: –meta-analysis-se-career flag added, to possess interoperation which have previous PLINK 2.0 logistic regression efficiency (and this spends an effective ‘LOG(OR)_SE’ community name to disambiguate the standard error’s products).
Repaired “–design gen” permutation research bug
twenty four October: Fixed uninitialized-variable bug into the –serving + –q-score-assortment. “–indep-pairwise 500kb . ” really works safely once more (the earlier build expected a space before ‘kb’).
4 Mar: Supports inside the demand-line let text are now actually used in a means alot more similar to other equipment. –testing today really works securely whenever a great numeric dispute was step 1 past the conclusion.
twenty six Could possibly get (beta 6): –merge-equal-pos bugfixes. For many who put –merge-equal-pos that have .bed+.bim+.fam filesets in which allele buy possess differed between .bim documents, otherwise having people .ped+.map fileset sito single incontri barba after all, we recommend redoing that run.
: –meta-research ‘report-all’ now accounts brand spanking new stats as opposed to ‘NA’ when Letter=step 1. Fixed an enthusiastic inaccuracy inside –adjust’s handling of really small p-philosophy. –make-just-fam performs safely in just .fam enter in once again.
14 The fall of (beta 5): –file + –merge[-list] bugfix. chart file was unsorted, but when you feel the opportunity i encourage redoing any –document + –merge and –file + –merge-number multi-.ped merges did that have before plink step 1.nine stimulates. (.sleep consolidating are unchanged, and –merge-record instead of –document try about never ever affected.)
fifteen Oct: A2 allele has become continuously reference into chr3 in our 1000 Genomes phase step one packages. As a general rule, you shouldn’t be prepared to keep REF/ALT alleles upright with PLINK step one.x, however, i attempted to create A2 constantly source within these records whilst still being didn’t some create; disappointed about that. (As to why is it receive today, over 2.five years after the facts? Due to the fact PLINK 2.0 presently has an excellent –ref-from-fa flag that will without difficulty seek such error.)
13 Oct: “–freq counts” don’t brings reversed show when alleles were turned out of the initial .bim/.sleep purchase. Fixed –logistic insect that will bring about spurious NA overall performance.
7 Oct: Fixed place-situation (a couple of five haplotypes have no known findings) insect during the –ld/–r2/–blocks/–clump’s mathematical phasing techniques. 32-portion make can type >2GB .sleep documents instead of crashing. –annotate and you can –gene-statement now focus on –allow-extra-chr.
fifteen Aug: –lasso is to now work properly whenever there are examples with covariates present nevertheless head phenotype forgotten.
21 Could possibly get: “–linear telecommunications intercourse” and you can “–logistic interaction sex” today work properly when no covariates are present. –tucc placed into creativity build.
20 February (beta 4): –pca var-wts today profile allele codes. Slight analytical phasing bugfix. –[max-]mac, –R, and you may –thin-indiv[-count] not classified just like the erratic. PLINK 2.0 leader produces are now actually available.
So it insect was more likely to end up in if the first
thirteen November: –geno/–shed today lose heterozygous haploid calls while the nonmissing; this is certainly consistent with –notice, and you may PLINK step 1.07’s choices having –recode/–make-sleep active. These are generally now contradictory in what PLINK step 1.07 did in the place of –recode/–make-bed; explore –make-bed + –set-hh-missing earliest if you’d like the outdated choices. “–ci 0.95” don’t provides ‘L94’/’U94’ line names when plink gets unlucky which have rounding. Small –exclude/–extract/–flip bugfix getting enter in data without newline at the bottom. –qfam[-within] bugfix. –amount ‘sex’ modifier today functions safely whenever specific examples was indeed blocked aside (age.g. given that particular phenotypes was basically shed).
20 Sep: VCF export don’t removes an enthusiastic alt allele missing regarding the instantaneous dataset, due to good retroactive enhance toward VCF specification.